Cleveland Clinic Receives $7.9 Million Grant from NIH to Form Radiation Oncology-Biology Integration Network (ROBIN)
Precision cancer medicine is the goal of a new multidisciplinary study, led by Dr. Tim Chan, examining radiation therapy combined with targeted therapy
New Cleveland Clinic Centers of Excellence Target “Long COVID,” Myeloid Leukemia, Gut Microbiome
The program, which has funded 21 research teams since 2015, has a proven record of supporting projects that go on to attract large external grants.
HSD3B1 Research Shows Association Between Genotype and Endometrial Cancer
Latest novel finding adds to list of cancers associated with the HSD3B1 gene; clinical and research teams investigating potential connections.
New Research Sheds Light on “Evolutionary Games” between Cancer and Healthy Cells in Targeted Therapy-Resistant Lung Cancer
Understanding cell growth dynamics may be the key to controlling therapeutic resistance.
Researchers Find Potential for Repurposing Drug to Target Certain Types of Leukemia Cells
Drs. Jha and Maciejewski have identified eltrombopag as a potent inhibitor of specific leukemia cells, which could lead to new drugs that target leukemia cells while preserving and expanding normal blood cells.
Cancer Treatment Approach Developed by LRI Researchers Proven Feasible in Clinical Study
Dr. Scott invented a new radiation planning technique called Temporally Feathered Radiation Therapy to reduce toxicity, which has now been shown to be safe and feasible in a small clinical study.
Study Confirms Effectiveness of New Personalized Approach for Radiation Therapy
Dr. Scott and colleagues validated the genomic-adjusted radiation dose to be beneficial as a pan-cancer predictor of radiation therapy efficacy in new clinical study.
LRI Postdoc Selected for Esteemed Howard Hughes Medical Institute Fellowship
Dr. Card, a postdoctoral fellow in the Scott lab, has been named a 2020 Hanna Gray Fellow, a fellowship that helps provide support for underrepresented and early-career biomedical researchers.
Concurrent Chemotherapy and Antibiotic Use Associated with Epithelial Ovarian Cancer Outcomes
Findings from a new retrospective study reveal that caution should be practiced when prescribing antibiotics to patients as antibiotic therapy is associated with decreased overall survival among women with the ovarian cancer.
Combining Genomics and Mathematics Helps Personalize Radiation Therapy for Lung Cancer
Rather than a one-size-fits-all approach, new technology from Dr. Scott provide opportunity to choose personalized radiation dose to improve outcomes and reduce toxicity.
Cancer Researchers Identify Potential New Class of Drugs to Treat Blood and Bone Marrow Cancers
Drs. Maciejewski and Jha developed a small molecule that selectively targeted and effectively eliminated cancer cells with a certain genetic mutation in preclinical models of myeloid leukemia, while simultaneously granting survival advantage to healthy cells.
Adapting Ideas from Quantum Physics to Calculate Alternative Interventions for Infection and Cancer
A team co-led by Dr. Scott shows for the first time how ideas from quantum physics can be translated and applied to biological problems, laying the foundation for a potential new area of study entirely, called quantum-inspired biological control.
Department of Defense Awards $2.4M for Bladder Cancer Immunotherapy Research
Drs. Mian, Gupta and Hwang—a multi-disciplinary team of researchers and clinicians—will look for ways to optimize immune checkpoint inhibitor therapy, including testing novel combinatory treatments and identifying predictive biomarkers of treatment response.
Understanding the Balance Between Ecological and Evolutionary Contributors to Cancer
Using Artificial Intelligence to Deliver Personalized Radiation Therapy
Five Researchers Win Annual Fund Grants
When Cancer Cells Compete: Measuring Evolutionary 'Games' in Cancer
Research Team Identifies Mutation that Promotes Liver Cancer