Lerner Research Institute News

Read about the latest advances from Lerner Research Institute scientists, including new findings, grant awards, innovations and collaborations.

2022

 

Processing flavonoids, nutritional components of “superfoods,” requires specific gut bacteria
11/30/2022

Cleveland Clinic researchers find that despite general benefits from fruits and vegetables, people need the right gut microbiota to reap the benefits from flavonoids.

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Uncovering the Essential Role Nitric Oxide Plays in Improving Disease Treatments
11/29/2022

Cleveland Clinic researchers discover connections between nitric oxide and heme proteins in regulating critical cellular and tissue signaling and physiological functions.

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Cleveland Clinic researchers collaborate with international team to uncover how the body responds to life-threatening disease from herpes simplex virus 1
11/29/2022

Researchers revealed novel genetic alterations and immune mechanisms in a child that was hospitalized with herpes encephalitis.

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Cleveland Clinic researchers create AI tool for Alzheimer’s target and drug discovery
11/29/2022

The open-source artificial intelligence (AI) technology uses human genetic data to identify candidate drugs.

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Restoring the gut biome after antibiotics could lead to better outcomes for ovarian cancer patients
11/07/2022

Reassessing antibiotic dosage and type could improve survival rates in deadliest gynecologic malignancy, Cleveland Clinic research finds.

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Dr. J. Bradley Randleman receives $1.5 million to study Brillouin spectroscopy
11/04/2022

Researchers study Brillouin spectroscopy to provide additional treatment options for patients with keratoconus.

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Cleveland Clinic study identifies blood pressure drug as potential treatment for Black patients with Alzheimer’s disease
11/04/2022

Analyzing data from more than 5 million patients revealed telmisartan is associated with lower Alzheimer’s disease incidence in Black patients, providing clues for potential treatment and prevention.

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Low-fat or lower-carb diet? Cleveland Clinic postdoc wins prestigious award to study dietary interventions for prostate cancer
11/02/2022

The Prostate Cancer Foundation awarded Ashley E. Holly, PhD, MBA, with the Young Investigator Award to study clinical investigations into diet and prostate cancer.

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Cleveland Clinic analysis provides new details on effects of COVID-19 on diabetes, blood sugar
10/27/2022

Researchers found that, despite previous reports, blood sugar increases were not significantly different in COVID-19 positive and negative patients.

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Cleveland Clinic receives $12 million to investigate how inflammatory cytokines affect cancer progression
10/14/2022

A new program funded by a National Cancer Institute grant aims to advance treatments that target the mechanisms tumors use to grow and survive.

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Metformin identified as a potential atrial fibrillation treatment in collaborative research
10/11/2022

How drugs and atrial fibrillation affect functions and genes in the body is the subject of a recent study into metformin and other candidate drugs.

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COVID-19 Virus-Human Protein Network Provides New Tools and Strategies for Screening Host-Targeting Therapies
10/10/2022

Cleveland Clinic researchers utilize artificial intelligence to create a discovery tool by outlining interactions between viral and host proteins.

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Cleveland Clinic Selected as Founding Partner in Greater Washington, D.C. Quantum Computing Hub
09/30/2022

Life Sciences and Healthcare Quantum Innovation Hub to be developed by Connected DMV to accelerate innovation, collaboration in quantum computing projects.

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Cleveland Clinic Receives $7.9 Million Grant from NIH to Form Radiation Oncology-Biology Integration Network (ROBIN)
09/23/2022

Precision cancer medicine is the goal of a new multidisciplinary study, led by Dr. Tim Chan, examining radiation therapy combined with targeted therapy

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New Cleveland Clinic Centers of Excellence Target “Long COVID,” Myeloid Leukemia, Gut Microbiome
09/23/2022

The program, which has funded 21 research teams since 2015, has a proven record of supporting projects that go on to attract large external grants.

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Florida Research and Innovation Center Team Discovers New Signal for Triggering Human Immune Response
09/15/2022

Cytoskeleton disturbance is key in inducing immune response; multi-trigger immune system signaling holds implications for vaccines, therapeutics.

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Cleveland Clinic Receives $2.9 Million for Additional Research on Emerging Tick-borne Virus Pathogen
09/15/2022

Dr. Jae Jung will study the natural course of infection and viral reassortment of the emerging pathogen, Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV).

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Cleveland Clinic MD-PhD Student Identifies Potential Therapeutic Target for Glioblastoma
09/14/2022

The research in Dr. Justin Lathia’s lab clarifies SerpinB3’s role in preventing cancer stem cell death, could lead to more effective radiation therapies.

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Dr. Andrei Ivanov Receives $2.5 Million to Study Invading Pathogenic Bacteria
09/09/2022

Research will explore the complex roles of cytoskeletal motors in regulating gut epithelila interaction with bacterial pathogens to develop new defensive therapeutics.

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HSD3B1 Research Shows Association Between Genotype and Endometrial Cancer
09/08/2022

Latest novel finding adds to list of cancers associated with the HSD3B1 gene; clinical and research teams investigating potential connections.

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Dr. William Dupps, Jr. Receives $2.4 Million to Develop Advanced Imaging and Simulation Tools for Personalized Eye Care
09/06/2022

Generating a virtual copy of the eyes to create personalized surgical plans will help lower operative risks and improve outcomes for patients with corneal disease.

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Dr. Stephanie Hagstrom Receives $2 Million to Study Tubby-Like Proteins (TULPs)
09/02/2022

Researcher aims to discover the function TULP1 gene plays in the blinding disease, retinitis pigmentosa.

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American Heart Association Panel Led by Cleveland Clinic Researchers Recommends More Research Into Sleep-disordered Breathing, Cardiac Arrhythmias
08/22/2022

Experts state conducting more research on heart arrhythmia and sleep-disordered breathing can help clarify how to treat or prevent both widespread conditions.

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Not Just Cholesterol: Cleveland Clinic, Tufts Red Meat Study Elaborates on Gut Bacteria’s Role in Forecasting Heart Disease
08/17/2022

Building on more than a decade of research from Dr. Stanley Hazen’s lab, researchers explored how elevated levels of trimethylamine N-Oxide (TMAO) could serve as a warning sign for heart disease

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Photoreceptor Regeneration and Immunosuppression in Inherited Retinal Dystrophy
08/16/2022

Zebrafish models offer a link between Notch signaling and the role of inflammation in slowing photoreceptor degeneration.

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Researchers Map Human Ureter Cell Populations to Pave the Way for Regenerative Medicine
08/03/2022

A multidisciplinary research team co-led by Dr. Angela Ting and Dr. Byron Lee has conducted a comprehensive analysis of the cell populations within the human ureter.

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Tumors with Specific Genetic Mutations Show Response to Immune Checkpoint Blockade Therapy
07/11/2022

Dr. Tim Chan demonstrated that pathogenic POLE/POLD1 mutations lead to improved response to immune checkpoint blockade therapy.

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Refining Thyroid Cancer Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome
07/11/2022

A study led by Dr. Eng suggests that patients with PTEN hamartoma tumor syndrome may require less frequent thyroid cancer surveillance than current guidelines recommend.

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The Future of CAR T-Cell Therapy
07/06/2022

Dr. Melenhorst is leading research to improve the safety, efficacy and access of emerging therapies.

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New Research Sheds Light on “Evolutionary Games” between Cancer and Healthy Cells in Targeted Therapy-Resistant Lung Cancer
07/06/2022

Understanding cell growth dynamics may be the key to controlling therapeutic resistance.

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Dr. Mina Chung and Team Receives $14.2 Million from NIH for Research into New Atrial Fibrillation Treatments
07/01/2022

Researchers aim to use genomic findings to identify novel therapeutics.

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Researchers Discover Young-Onset Colorectal Cancer Mortality Hot and Cold Spots
06/23/2022

Dr. Schmit and colleagues identified geographic hot and cold spots of young-onset colorectal cancer mortality in the United States in order to highlight regions for further investigation and future preventive interventions.

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New Global Center for Pathogen & Human Health Research Paving the Way for National Pandemic Research Participation
06/20/2022

Cleveland Clinic researchers to participate in NIH consortium focused on antiviral drug development.

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Dr. Thaddeus Stappenbeck Appointed to the Sherwick Endowed Chair in Inflammation and Immunity
06/10/2022

The Sherwick Endowed Chair provides impactful research opportunities to improve understanding of the immune system and inflammatory diseases and develop better preventive and therapeutic responses.

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Researchers Find Potential for Repurposing Drug to Target Certain Types of Leukemia Cells
05/19/2022

Drs. Jha and Maciejewski have identified eltrombopag as a potent inhibitor of specific leukemia cells, which could lead to new drugs that target leukemia cells while preserving and expanding normal blood cells.

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Flipping the Switch on Prostate Cancer Immunotherapy
05/18/2022

Dr. Nima Sharifi and a team of researchers uncovered how tumors circumvent prostate cancer therapy and identified a potential window of time after treatment when tumors may be responsive to immunotherapy.

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Exploring a Blood-Based Biomarker of Inflammation for Alzheimer’s Disease
05/16/2022

Dr. Bekris’ team found that patterns of sTREM2-related inflammatory activity were specific to Alzheimer’s disease stages.

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Dr. Justin Lathia Named One of Only Nine Recipients of National Research Program Award
05/12/2022

Dr. Lathia has received an eight-year, $5.2 million award from the National Institute of Neurological Disorders and Stroke to further research into the dynamics of immune suppression in malignant brain tumors and target future immune-activating therapies.

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NIH Grant to Advance the Study of Cholestatic Liver Diseases
05/12/2022

Dr. Sakaguchi and his team will investigate the molecular mechanisms and malfunctions of the biliary system to develop new treatments for liver diseases.

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New Research Collaborative Aims at Closing Minority Health Disparities
05/04/2022

With a Cleveland Clinic research co-laboratories award, Drs. Schmit and Mata will establish the Cleveland Clinic Latino Epidemiology (CCLE) Cohort to help close the gap in research participation and health disparities for the Latino population.

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Cleveland Clinic Appoints Ted Ross, PhD, as Global Director of Vaccine Development
04/28/2022

In this newly created role, he will lead the development of novel vaccine platforms for a variety of infectious diseases, including influenza, HIV and COVID-19.

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MCL1 in the Nucleus Appears to Drive Chemoresistance in Colorectal Cancer
04/25/2022

Dr. Gastman and collaborators have published findings indicating Bcl-xL inhibitors may help overcome this complication.

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The STAR Consortium Awarded $5.3 Million from the Helmsley Charitable Trust to Develop Next Generation Biomarker Tools for Crohn’s Disease Patients
04/13/2022

The STAR consortium, led by coordinating PI Dr. Rieder, seeks to identify and develop novel biomarkers to help establish effective therapeutics for Crohn’s disease patients with fibrosis.

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First Research Published Using Cleveland Clinic’s COVID-19 Study Samples Provides Glimpse into Potential New Treatments
04/07/2022

Dr. Jung and his team of researchers published the novel COVID-19 study, which details the critical role viral gene ORF8 plays in infection and outcomes rates, using samples from Cleveland Clinic’s BioRepository.

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Cleveland Clinic Appoints Key Leadership to Center for Immunotherapy & Precision Immuno-Oncology
03/15/2022

J. Joseph Melenhorst, PhD, has been appointed director of the new Cell Therapy and Immuno-Engineering Program, and Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.

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Characterizing Dermatologic Findings in PTEN Hamartoma Tumor Syndrome
03/14/2022

Dr. Eng and colleagues conducted a multi-center analysis of skin findings in patients with PTEN hamartoma tumor syndrome.

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Metabolites May Influence Cancer Versus Autism Risk in PTEN Hamartoma Tumor Syndrome
03/10/2022

Dr. Eng’s team found that distinct metabolite profiles may be associated with either cancer or autism spectrum disorder and/or developmental delay in individuals with PTEN hamartoma tumor syndrome.

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BME Researcher Receives Award from the Clinical Research Forum for Pioneering Bionic Arm Study
03/10/2022

Dr. Marasco was honored for engineering a prosthetic that allows the wearer to “think” and function like an able-bodied person.

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Prediction Model Aids in the Early Diagnosis of Dravet Syndrome
03/07/2022

Dr. Lal and colleagues have developed a statistical model that integrates genetic and clinical data to calculate the probability of developing Dravet syndrome.

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Cleveland Clinic Researchers Receive Two Grants to Study Pathogenesis of Multiple Sclerosis
03/03/2022

Dr. Dutta is collaborating with other Cleveland Clinic researchers to explore possible novel causes of disease progression in multiple sclerosis, as well as potential therapeutic targets.

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New Model May Predict Immunotherapy Response in Melanoma Patients
03/02/2022

Dr. Gastman’s team found that high levels of a CD8 T-cell subpopulation may predict immune checkpoint inhibitor therapy resistance in melanoma.

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NIH Funds Multi-Institutional Training Network to Support Kidney, Urologic and Hematologic Research
02/21/2022

Drs. Sedor and Boron are leading a collaboration of Cleveland biomedical institutions to address gaps in community health and training

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Cleveland Clinic Model Predicts the Risk of Hospital Readmissions
02/16/2022

Dr. Misra-Hebert and colleagues assessed a Cleveland Clinic model’s ability to predict the likelihood that a patient would need to be readmitted to the hospital within 30 days of discharge.

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Lerner-Developed Flow Cytometry Best Practices Lay Groundwork for Global Recommendations
01/26/2022

Dr. Asosingh’s team developed new Shared Resource Laboratory (SRL) guidelines, including user consultations, to ensure experimental success and accuracy.

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Investigating Age Differences in COVID-19 Immune Response
01/13/2022

Dr. Cheng’s team identified several differences in immune and inflammatory responses that may help explain the elevated risk for severe illness and death observed in older COVID-19 patients.

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Adaptive Differentiation Drives Cell Repair in Diseased Tissues
01/12/2022

Dr. Stappenbeck’s group found a new cell type that is produced by intestinal epithelial stem and progenitor cells and provides rapid structural support to damaged, high-turnover tissue and a foundation for its proper healing.

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