Cleveland Clinic’s Musculoskeletal Research Center (MSRC) brings together researchers across the spectrum of biomedical discovery—translational scientists and engineers, orthopaedic surgeons, radiologists and imaging scientists, rheumatologists, physiatrists, pathologists, neuroscientists, and biostatisticians—to discover, translate and innovate to improve patient care.


Musculoskeletal disorders and diseases are the leading cause of disability in the United States and account for more than half of all chronic conditions in people over 50 years of age in developed countries (source: United States Bone and Joint Initiative).

Our mission is to advance the treatment, health and quality of life of people with disorders of the musculoskeletal system through basic, translational and clinical investigation and innovation, and to train future leaders in musculoskeletal care, research and education.

Multidisciplinary Collaboration

The MSRC fosters the collaboration of more than 70 investigators across the Cleveland Clinic enterprise in our core multi-disciplinary research programs in the areas of Arthritis, Arthroscopy, Bone Biology and Disease, Musculoskeletal Imaging, Neuromuscular Conditions, Regenerative Therapies and Tendinopathies. Learn more about our members and research projects.

Our Pilot Project Program is available to support currently unfunded, innovative, disease-oriented projects that are in need of the early data that would make them competitive for extramural funding. Learn more about this program.

The MSRC creates a highly-supportive environment to advance education, research and translation through journal clubs, Think Tank, invited lecture series, annual symposium, and national/international specialty workshops. Learn more about our events.