The Future of Cancer Treatment

While traditional methods for treating cancer, including chemotherapy and radiation, are often effective at killing cancer cells, they can also kill healthy cells, as well. Cancer researchers around the world are searching for more effective therapies that do not compromise patients’ long-term health and wellness. One of the most promising research areas is immunotherapy, which has shown great promise in treating many types of cancer.

Immunotherapies, including immune checkpoint modulators and cell therapy, have revolutionized the treatment of many human diseases. They have improved the outcomes of many cancers to a level thought impossible even a few years ago and comprise a new family of treatments that are quickly becoming a foundation of modern medicine. Classic immunotherapies such as vaccines are becoming increasingly important in a world threatened by emerging pathogens and antibodies that target discrete molecules have helped patients control various autoimmune ailments.

The Center for Immunotherapy & Precision Immuno-Oncology (CITI) is a state-of-the-art center dedicated to immunotherapy research, discovery and developmental therapeutics, with the ultimate goal to make precision immuno-oncology available for every patient. Learn more about our mission and goals.

Our Research Divisions & Programs

Cell Therapy & Immuno-Engineering Program

Our program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.

Immunologic Medicine Research Division

Our division advances translational immunology research, specializing in the fields of immuno-oncology, auto-immunity, computational immunology and population immunology.


Precision Immuno-Oncology Platform

Our program brings enhanced clinical trials correlates and discovery capabilities to Cleveland Clinic and Case Comprehensive Cancer Center for a wide range of basic and clinical topics.


Precision & Developmental Therapeutics Program

Our program collaborates with the Cleveland Clinic Cancer Center and Case Comprehensive Cancer Center to provide precision approaches, including immunogenomic profiling, and new immunotherapy trials to patients and investigators.

What is Immunogenomics?

We are using immunogenomics—the combined study of tumor and immune cell genomics—to learn more about the body’s immune response to cancer, and how it can be imitated or amplified.


What is Precision Immuno-Oncology?

It is our ultimate goal to offer immunogenomic profiling to all patients receiving immunotherapy treatment, either through clinical trials or commercial treatments.


Cleveland Clinic Receives $7.9 Million Grant from NIH to Form Radiation Oncology-Biology Integration Network (ROBIN)

Precision cancer medicine is the goal of a new multidisciplinary study, led by Dr. Tim Chan, examining radiation therapy combined with targeted therapy

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Tumors with Specific Genetic Mutations Show Response to Immune Checkpoint Blockade Therapy

Dr. Tim Chan demonstrated that pathogenic POLE/POLD1 mutations lead to improved response to immune checkpoint blockade therapy.

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The Future of CAR T-Cell Therapy

Dr. Melenhorst is leading research to improve the safety, efficacy and access of emerging therapies.

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Highlighted Studies

View studies showcasing our latest discoveries and findings.


Join Us

Exciting investigation and groundbreaking discovery happens every day at Cleveland Clinic. Join our team of expert researchers at the Center for Immunotherapy & Precision Immuno-Oncology.